Enzyme Inhibition

What is the difference between allosteric, competitive and noncompetitive inhibition? Is non-competitive inhibition a type of allosteric inhibition?

@anangaur_52188
The two types of inhibition are competitive and noncompetitive inhibition


from Khan Academy

Competitive inhibition is when a molecule besides the substrate binds to the active site of the enzyme.

Noncompetitive inhibition is when a molecule binds to site other than the active site, known as an allosteric site. In noncompetitive inhibition, a substrate can still bind to the active site, but no products are made because the noncompetitive inhibitor is still bound to the allosteric site.
Allosteric inhibition is a type of noncompetitive inhibition. An allosteric inhibitor will bind to the allosteric site, which causes the active site to change its shape and won’t allow the substrate to bind.


from Khan Academy

Hope this helps :slight_smile:

Thank you so much! That makes so much more sense! So, increasing substrate concentration would increase the reaction rate for Competitive inhibition, but not for Allosteric inhibition because the substrate cannot bind no matter what. Would increasing the substrate concentration change the reaction rate for Noncompetitive inhibition?

@anangaur_52188
Increasing the substrate or enzyme concentration will increase the reaction rate because this increases the frequency the substrates bump into the enzymes, whether it is competitive or noncompetitive inhibition.

1 Like
Fiveable Logo

2550 north lake drive
suite 2
milwaukee, wi 53211

✉️ help@fiveable.me

learn

about for students for parents for teachers for schools & districts content team privacy contact

practice

🥇 2020 Fiveable Olympics study plans upcoming events trivia hypertyper resources cram passes

connect

community tiktok discord twitter instagram facebook careers

*ap® and advanced placement® are registered trademarks of the college board, which was not involved in the production of, and does not endorse, this product.

© fiveable 2020 | all rights reserved.