Noncompetitive inhibitor

if the active site is mutated, can a noncompetitive inhibitor still bind to the enzyme?

no, a noncompetitive inhibitor only binds to a differenct site

it binds to the enzyme at an allosteric site which does not compete with the enzyme but blocks the reaction between the substrate and the enzyme from occurring

Usually, an allosteric activator will bind to an allosteric site to change the active site of the enzyme, and thus will allow the substrate to bind to the enzyme once more.

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